cause someone to feel intense discomfort or irritation
This is an expression used in the Bible to describe the unpleasant sensation caused by eating something bitter or sour : every man that eateth the sour grape, his teeth shall be set on edge (Jeremiah 31 : 30).
1997 - Kate O'Riordan - The Boy in the Moon Julia's voice sustained a quavery note that set Brian's teeth on edge.
RELATED IDIOMS :
on the edge of your seat = on the edge of your chair
very excited and giving your full attention to something – informal
take the edge off something
reduce the intensity or effect of something, especially something unpleasant or severe.